To outline the synthetic route of metopimazine, we need to break it down into its key steps. Metopimazine is a drug used to treat nausea and vomiting. Let’s go through the synthesis process step by step.

Solution By Steps

Step 1: Formation of 2-Chloro-3-methylpyridine

Starting with 2,3-dimethylpyridine, react it with thionyl chloride (SOCl2) to replace one methyl group with a chlorine atom.

Step 2: Formation of 2-Chloro-3-methylpyridine-5-sulfonamide

React the 2-chloro-3-methylpyridine with sulfamide to introduce a sulfonamide group at the 5-position.

Step 3: Formation of 2-Chloro-3-methylpyridine-5-sulfonamide-4-carboxylic acid

Oxidize the sulfonamide group to a sulfonic acid using a suitable oxidizing agent.

Step 4: Formation of Metopimazine

React the 2-chloro-3-methylpyridine-5-sulfonamide-4-carboxylic acid with 2-dimethylaminoethyl chloride hydrochloride to form metopimazine.

Final Answer

The synthetic route of metopimazine involves the formation of 2-Chloro-3-methylpyridine, followed by the introduction of a sulfonamide group, oxidation to a sulfonic acid, and finally, the formation of metopimazine.

Key Concept

Organic Synthesis

Key Concept Explanation

Organic synthesis involves the creation of complex organic compounds from simpler starting materials through a series of chemical reactions. It is crucial in pharmaceuticals to produce drugs like metopimazine efficiently and reliably.